Christopher V. Carman
Assistant Professor of Medicine
Department of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
Center for Vascular Biology Research
99 Brookline Avenue
Research North, RN-234
Boston, MA 02215
| Phone: | 617-667-0888 |
| Fax: | 617-667-2913 |
Major Research Interests:
Vascular and Cell Biology of Inflammation and Wound Healing
Our laboratory investigates the cell biological basis of inflammation and wound healing with special emphasis on leukocyte-endothelial interactions. The vascular endothelium is the monolayer of cells that lines the cardiovascular system and serves as the critical barrier between the tissues and the blood. Thus, the endothelium is strategically positioned to serve as a unique sentinel for communicating interstitial information to the circulating immune cells (i.e., leukocytes). In this way, the endothelium plays critical roles in directing the trafficking patterns, as well as activation states of leukocytes. The endothelium can also become damaged by inappropriate immune/inflammatory responses, creating a dysfunctional barrier that gives rise to many of the pathogenic features of inflammatory diseases such as sepsis, anaphylaxis, multiple sclerosis and arthritis. Our work makes extensive use of advanced fluorescence imaging, electron microscopy and biomechanical approaches to understand the fundamental basis and consequences of leukocyte-endothelial interactions and how they may become perturbed during inflammatory and immune-related diseases. Topics we are currently investigating include:
Education:
| 1994 | B.S. | University of New Hampshire, Durham, NH (Biochemistry) |
| 1999 | Ph.D. | Thomas Jefferson University, Philadelphia, PA (Molecular Pharmacology & Structural Biology) |
Postdoctoral Training:
| 1999-2004 | Cell Adhesion and Migration in the Immune System, Immune Disease Institute, Harvard Medical School, Boston, MA (Timothy A. Springer) |
Academic Appointments:
| 2004-2006 | Instructor | Department of Pathology, Harvard Medical School |
| 2006 | Instructor | Department of Medicine, Harvard Medical School |
| 2006- | Assistant Professor | Department of Medicine, Harvard Medical School |
Awards and Honors:
| 1993 | Undergraduate Research Opportunities Program Award |
| 1996-1998 | U.S. Department of Health PHS Fellowship |
| 1998 | Thomas Jefferson University Alumni Fellowship |
| 1999 | Sigma Xi Student Research Award |
| 2000 | Thomas Jefferson University Alumni Outstanding Thesis Prize |
| 2000-2002 | American Heart Association Postdoctoral Fellowship |
| 2003-2005 | NRSA Fellow, Postdoctoral Training Program in Cancer Immunology |
| 2005 | Arthritis Investigator Award |
Professional Societies:
| 2001- | Member, Biophysical Society |
| 2005- | Member, The American Society for Cell Biology |
| 2007- | Member, Federation of Clinical Immunology Societies Center of Excellence |
| 2008- | Member, The Invadosome Consortium |
Major Committee Assignments:
| 2006- | Member, Center for Vascular Biology Research Planning Committee, BIDMC |
| 2006- | Chair, Center for Vascular Biology Research Website Development Committee, BIDMC |
| 2006- | Mentor, BioMatrix (Harvard-MIT Division of Health Sciences and Technology mentoring community), HST |
| 2007- | Member, Harvard Immunology Resource Committee, HMS |
| 2008- | Member, Gwangju Institute of Science and Technology International Peer Review Committee |
Editorial Boards:
| 1999- | Ad hoc reviewer, Journal of Biochemistry |
| 2000- | Ad hoc reviewer, Biochemistry |
| 2003- | Ad hoc reviewer, Journal of Immunology |
| 2005- | Ad hoc reviewer, Journal of Cell Biology |
| 2006- | Ad hoc reviewer, Molecular Biology of the Cell |
| 2007- | Ad hoc reviewer, Blood |
| 2007- | Ad hoc reviewer, American Journal of Physiology: Cell Physiology |
| 2007- | Ad hoc reviewer, Nature |
| 2007- | Ad hoc reviewer, American Journal of Physiology: Cell Physiology |
| 2008- | Ad hoc reviewer, Journal of Thrombosis and Haemostasis |
| 2008- | Ad hoc reviewer, Journal of Reproductive Immunology |
| 2008- | Ad hoc reviewer, The Anatomical Record |
| 2008- | Ad hoc reviewer, The Journal of Experimental Medicine |
| 2009- | Ad hoc reviewer, The European Journal of Immunology |
| 2009- | Ad hoc reviewer, Cancer Research |
Teaching Experience:
| 2007 | Lecturer, Harvard Medical School, Human Physiology and Pathophysiology, DMS220 |
| 2007-2009 | Lecturer, Harvard Medical School, Immunology 202, Imm202 |
Selected Lectures:
| 2004 | Invited Presentation, Japanese Society for Cell Biology 57th Annual Meeting, Osaka, Japan |
| 2005 | Invited Lecture, University of North Carolina, Chapel Hill |
| 2005 | Invited Lecture, University College of London, Institute of Ophthalmology, London, England |
| 2005 | Invited Lecture, Oxford University, Weatherall Institute of Molecular Medicine, Oxford, England |
| 2005 | Speaker, “Leukocyte Trafficking” Keystone Meeting, Taos, New Mexico |
| 2005 | Invited Lecture, Brown University Medical School, Division of Biology and Medicine, Providence, RI |
| 2006 | Invited Lecture, The Schepens Eye Research Institute, Boston, MA |
| 2006 | Invited Lecture, Harvard Medical School, Vascular Biology Seminar Series, Boston, MA |
| 2007 | Invited Lecture, Dartmouth Medical School, Department of Microbiology and Immunology, Hanover, NH |
| 2007 | Speaker, Annual Meeting of the Society for Microcirculation and Vascular Biology, Heidelberg, Germany |
| 2007 | Invited Lecture, Organon Research Center, Organon Biosciences, Cambridge, MA |
| 2008 | Speaker, “Cell Migration in Invasion and Inflammation” Keystone Meeting, Taos, New Mexico |
| 2008 | Opening Address, “International Conference on Adhesion Molecules in Red Cell Endothelium Interactions”, Paris, France |
| 2008 | Invited Lecture, VU University Medical Center, Amsterdam. The Netherlands |
| 2008 | Keynote Address, “Signal Transduction in the Blood-Brain Barriers”, Amsterdam, The Netherlands |
| 2008 | Speaker, “Ringberg Symposium: Molecular Mechanisms in Leukocyte Traffic”, Ringberg, Germany |
| 2008 | Speaker, “The 9th International Congress on Cell Biology”, Seoul, Korea |
| 2008 | Speaker, “The 1st Annual International Symposium of the Cell Dynamics Research Center”, Gwangju Institute of Science and Technology, Gwangju, Korea. |
| 2008 | Invited Lecture, University of Pennsylvania Immunology Colloquium, Philadelphia, Pennsylvania |
| 2009 | Invited Lecture, University of Miami Miller School of Medicine, Miami, Florida |
| 2009 | Speaker, Aso International Meeting on Thrombosis, Hemostasis and Vascular Science, Kumamoto, Japan |
| 2009 | Invited Lecture, University of Virginia, Biomedical Engineering Department, Charlottesville, Virginia |